Boris Johnson is self-isolating after meeting an MP who later tested positive for Covid-19.
The prime minister said he was contacted by NHS Test and Trace on Sunday but is not showing symptoms.
Mr Johnson on Thursday spent about 35 minutes with Ashfield MP Lee Anderson who has since tested positive.
The news came as No 10 said Mr Johnson would make “critical announcements” about coronavirus and “levelling up” the UK over the coming weeks.
In an announcement planned before Mr Johnson was told to self-isolate, Downing Street said there would be a “clear signal” of his “ongoing ambitions for the United Kingdom”.
It said Mr Johnson would chair “key Covid meetings” and work with Chancellor Rishi Sunak to devise the upcoming spending review with an aim to fulfil his promise to “build back better”.
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But No 10’s effort to start the week afresh following the departure of two of Mr Johnson’s top aides amid an internal power struggle was overshadowed by news the prime minister was self-isolating.
Mr Johnson wrote on Twitter on Sunday night: “Today I was notified by NHS Test and Trace that I must self-isolate as I have been in contact with someone who tested positive for COVID-19.
“I have no symptoms, but am following the rules and will be working from No 10 as I continue to lead the government’s pandemic response.”
A No 10 spokesman added: “The PM is well and does not have any symptoms of Covid-19.”
‘I’ve been pinged!’
In a WhatsApp message to Tory MPs seen by the BBC the PM added: “The good news is that NHS Test and Trace continues to improve. The bad news is that I have been pinged!”
He said that he would observe self-isolation rules despite “following the guidance and socially distancing” during his meeting with Mr Anderson.
“It doesn’t matter that I feel fine – better than ever – or that my body is bursting with antibodies because I have already had the damn thing,” he added.
“The rules are the rules and they are there to stop the spread of the disease.”
In April, Mr Johnson spent three nights in intensive care after falling ill with the virus.
He later said it “could have gone either way” and thanked healthcare workers for saving his life.
‘Timing couldn’t be worse’
Boris Johnson will now have to stay at home in No 10.
It means he will not be able to be in Parliament, though I’m told he will be working from Downing Street.
He does still intend to keep communicating with the country.
It was supposed to be a pretty big week for Boris Johnson – he is trying to reset his government after some factional fighting in his office over the last few days.
There are conversations taking place with the parliamentary authorities to see whether he can still contribute to the Commons.
I think it is fair to say this has not come at the best time for Mr Johnson: he has big decisions to make on Brexit and what happens when England’s lockdown ends on 2 December.
And it is also worth bearing in mind he was extremely ill with coronavirus earlier in the year and we do not know what getting the virus does for a person’s immunity.